Catherine M Sniezek

This study evaluates how detergent selection and timing affect thermal stability proteomics results, finding that DDM improves detection of some drug-target interactions but may obscure others.

This study compares the effects of two IL-6 inhibitors on serum extracellular vesicles using proteomics, finding distinct protein pathway alterations.

The paper profiles molecular responses to HDAC inhibitors in diverse cell lines, revealing heterogeneous protein remodeling and cell-type specific effects.

This paper designs a synthetic ligand, H2F, that induces HER2-FGFR proximity to reprogram fibroblasts into myogenic cells and promote myogenic regeneration.

The paper designs TrkA agonists that activate neuronal differentiation and neurite outgrowth without triggering pain-related gene expression.

This study uses proteome-wide thermal shift assays to analyze over a million thermal stability measurements from 96 compounds in cells and 70 in lysates, revealing target engagement and off-target effects.