Evan P. Hass

The paper introduces MPRNA-IP, a method to dissect RNA-protein interactions in vivo using custom RNA pools and statistical models to identify binding domains and structures.

The paper identifies a 4-base pair core-enclosing helix in telomerase RNA essential for binding TERT and telomerase activity in yeast.

This study shows that repositioning the Sm-binding site in yeast telomerase RNA affects 3′-end formation and highlights the flexibility of the telomerase RNP structure.

The paper introduces a CRISPR-based yeast two-hybrid system to identify RNA-binding proteins, demonstrating its effectiveness in detecting RNA-protein interactions with high sensitivity.