Pawan Kumar Jha

Sleep regulates hepatic neutrophil trafficking by modulating uric acid metabolism via sympathetic nervous system activity

This study shows that sleep loss triggers hepatic inflammation through a sympathetic-metabolic-immune axis by increasing uric acid synthesis and neutrophil recruitment.

An integrative analysis of cell-specific transcriptomics and nuclear proteomics of sleep-deprived mouse cerebral cortex

This study investigates how sleep deprivation affects gene expression and nuclear protein abundance in neurons and astrocytes using integrated transcriptomics and proteomics.

Chronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice

This study identifies complement and coagulation pathway activation as a mechanism by which chronic sleep restriction accelerates brain aging in mice.

Exposure to rotenone triggers redox driven systemwide lipidome alterations and metabolic tradeoffs linked to Parkinsons disease

This study examines how chronic rotenone exposure disrupts lipid metabolism and redox balance in Drosophila, linking these changes to Parkinson's disease-like phenotypes.

SlumberNet: Deep learning classification of sleep stages using residual neural networks

SlumberNet is a deep learning model that classifies sleep stages in mice with high accuracy and speed, showing potential for adaptation to human sleep analysis.

Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep

The paper uses single-cell RNA sequencing and cell-type specific proteomics to study sleep's molecular effects, finding cell-specific transcriptional, translational, and post-translational responses to sleep need.