Mathieu Nollet

This study shows that amyloid accumulation in medial septal cholinergic neurons of aging mice leads to REM sleep loss, cognitive and emotional deficits, and amyloid spread to other brain regions.

This paper identifies a REM-active basal ganglia circuit in mice that regulates REM sleep and anxiety by showing its role in sleep duration and behavioral responses to aversive stimuli.

The paper uses single-cell RNA sequencing and cell-type specific proteomics to study sleep's molecular effects, finding cell-specific transcriptional, translational, and post-translational responses to sleep need.

This study identifies REM sleep as a core response to chronic stress in mice, linking it to corticosterone regulation and apoptotic pathways through transcriptomic analysis.