Sarah D’Adamo

From Light to Lipids: Constraint-Based Metabolic Modeling of Nannochloropsis oceanica Under Light Acclimation Conditions

This paper develops a genome-scale metabolic model for Nannochloropsis oceanica to study lipid production under light acclimation conditions.

Design and analysis of synthetic carbon fixation pathways based on novel enzymatic reactions

This paper identifies novel carbon fixation pathways using bioretrosynthetic analysis and expert knowledge, finding several that could outperform the Calvin cycle in biomass yield and do not require vitamin B12.

Modular in vivo engineering of the reductive methylaspartate cycles for synthetic CO2 fixation

This paper designs and tests synthetic CO2 fixation pathways in E. coli, demonstrating their potential to outperform natural pathways.

A recursive pathway for isoleucine biosynthesis arises from enzyme promiscuity

The paper identifies a recursive isoleucine biosynthesis pathway in E. coli driven by the promiscuous activity of acetohydroxyacid synthase II, using glyoxylate and pyruvate directly instead of threonine.