Chi‐Hua Chen

The paper investigates the genetic architecture of cortical expansion and regionalization by comparing genome-wide association studies of 24 cortical regions with and without adjustment for global measures, finding distinct genetic loci associated with different regions.

The paper identifies eight drug candidates for repurposing to treat cognitive symptoms in schizophrenia, with sex-specific recommendations based on gene expression differences.

The paper investigates genetic correlations between psychiatric disorders, personality traits, and SARS-CoV-2 susceptibility using GWAS data and individual-level polygenic risk scores.

The paper identifies atypical genomic cortical patterning in autistic toddlers with poor early language outcome, linking it to prenatal developmental processes and later functional specialization.

This study uses multivariate GWAS on diffusion imaging data from two large datasets to identify 503 genetic loci affecting brain tissue composition and uncover molecular pathways related to axonal growth, synaptogenesis, and neuroinflammation.

The paper quantifies genetic overlap between cortical thickness and surface area using UK Biobank data, finding shared causal variants and suggesting more discoverable parcellation schemes.

This study demonstrates sex-dependent polygenic effects on Alzheimer’s disease progression by using polygenic hazard scores, showing stronger associations with clinical outcomes than traditional polygenic risk scores.

This paper identifies continuous cortical regionalization from embryonic stages to old age using longitudinal data and gene expression analysis.