Donald J. Hagler

Assessing nonlinear associations between body mass index and brain microstructure across adolescence in the ABCD Study

This study examines how BMI relates to brain microstructure across adolescence, finding nonlinear associations that intensify at higher BMI percentiles.

FEMA-Long: Modeling unstructured covariances for discovery of time-dependent effects in large-scale longitudinal datasets

FEMA-Long enables efficient modeling of time-dependent effects in longitudinal data, discovering genetic variants with time-dependent effects on infant growth traits.

Unintended bias in the pursuit of collinearity solutions in fMRI analysis

The paper identifies unintended bias from collinearity reduction strategies in fMRI analysis and introduces a contrast-based variance inflation factor to assess their impact.

Leveraging the Adolescent Brain Cognitive Development Study to improve behavioral prediction from neuroimaging in smaller replication samples

The paper uses the ABCD Study to determine optimal replication sample sizes for reproducible brain-behavior associations using neuroimaging data.

FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data

FEMA enables fast and efficient mixed-effects analyses of large-scale whole-brain imaging data, revealing distinct spatial patterns of brain maturation in early adolescence.

Multimodal Image Normalisation Tool (MINT) for the Adolescent Brain and Cognitive Development study: the MINT ABCD Atlas

The paper introduces MINT, a tool for multimodal MRI registration, and presents an ABCD atlas for whole-brain analysis, showing it outperforms existing methods in speed while maintaining accuracy.

Microstructural development from 9-14 years: evidence from the ABCD Study

The paper uses restriction spectrum imaging to analyze age-related microstructural changes in brain diffusion across 9-14 year olds from the ABCD Study, finding increased restricted diffusion in subcortical regions with age.

Multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

The paper uses a multivariate GWAS approach to identify 780 genetic loci associated with cortical morphology, showing a 10-fold increase in loci compared to univariate methods.

Atypical genomic cortical patterning in autism with poor early language outcome

The paper identifies atypical genomic cortical patterning in autistic toddlers with poor early language outcome, linking it to prenatal developmental processes and later functional specialization.

The genetic etiology of longitudinal measures of predicted brain ageing in a population-based sample of mid to late-age males

This study investigates the genetic and environmental factors influencing longitudinal predicted brain ageing (PBA) using MRI data from mid to late-age males, finding significant genetic heritability and stability over time.

Adolescent Brain Cognitive Development (ABCD) Community MRI Collection and Utilities

A curated collection of processed ABCD neuroimaging derivatives plus utilities for access, sharing and analysis, letting researchers exchange derivatives they cannot share through the central archive.

Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation

This study uses multivariate GWAS on diffusion imaging data from two large datasets to identify 503 genetic loci affecting brain tissue composition and uncover molecular pathways related to axonal growth, synaptogenesis, and neuroinflammation.

Associations between Early Midlife Lifestyle Behaviors, Young Adult Cognitive Reserve and Advanced Predicted Brain Age in Late Midlife

This study examines how early midlife lifestyle behaviors and young adult cognitive reserve influence late midlife brain aging and mild cognitive impairment.

Biophysical modeling of the neural origin of EEG and MEG signals

This paper presents a method to compute current dipoles from simulated neural activity to model EEG and MEG signals with biophysical detail.

Behavioral and neural signatures of working memory in childhood

The paper links working memory performance to brain activation patterns in children using fMRI data from a large longitudinal study.

Correction of respiratory artifacts in MRI head motion estimates

This paper develops a band-stop filter to correct respiratory artifacts in MRI motion estimates, improving data quality and demonstrating real-time implementation.

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

The paper describes neuroimaging processing methods for the ABCD Study to extract brain phenotypes from multimodal imaging data.

Brain structure mediates the association between height and cognitive ability

The paper investigates whether cortical size mediates the association between height and cognitive ability using twin data.

Heterogeneous origins of human sleep spindles in different cortical layers

This study identifies two distinct patterns of human sleep spindle generation in different cortical layers using microelectrode recordings and factor analysis.