Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains
Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew‐Yeu Peak‐Chew, Takashi Saito, Takaomi C. Saido, Jennifer A. Macdonald, Isabelle Lavenir, Bernardino Francesco Ghetti, Caroline Graff, Amit Kumar, Agneta K. Nordberg, , Sjors H. W. Scheres
The paper reports cryo-EM structures of amyloid-beta filaments with the Arctic mutation from human and mouse brains, revealing structural differences and conformational changes.
Acta Neuropathologica · Jan 7, 2023Peer-reviewedNeuroscience