Author
MRC Laboratory of Molecular BiologyORCID 0000-0001-8616-891XUnclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Shreyangi Chakraborty, Silvia Poggini, Michaela Rusková…·Maria M. Magiera
This study shows that reduced microtubule polyglutamylation causes neuronal dysfunction and worsens Tau-induced neurodegeneration in mice.
Manuel Schweighauser, Alexey G. Murzin, Jennifer A. Macdonald…·Michel Goedert
The paper determines cryo-EM structures of Tau filaments from transgenic mice models and identifies differences compared to human Tau filaments.
Yang Yang, Wenjuan Zhang, Alexey G. Murzin…·Sjors H. W. Scheres
The paper reports cryo-EM structures of amyloid-beta filaments with the Arctic mutation from human and mouse brains, revealing structural differences and conformational changes.
Yang Yang, Diana Arseni, Wenjuan Zhang…·Michel Goedert
Cryo-EM shows brain-derived Aβ42 filaments adopt two related S-shaped protofilament folds: Type I dominates sporadic Alzheimer's, Type II familial Alzheimer's, other disorders and App^NL-F knock-in mice.