Author

Colby A. Tubbs

University of North Carolina at Chapel HillORCID 0000-0001-7676-8735Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Douglas M. RuderferiD· 1 shared Evonne McArthuriD· 1 shared Hector L. FrancoiD· 1 shared John A. CapraiD· 1 shared Joseph P. GarayiD· 1 shared Li SheniD· 1 shared Mary Lauren BentoniD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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1 shared paperGenetics

Douglas M. RuderferORCID

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2 papers

Recent·Most cited

GeneticsThe American Journal of Human GeneticsPeer-reviewedMar 5, 2025

Identifying deleterious noncoding variation through gain and loss of CTCF binding activity

Colby A. Tubbs, Mary Lauren Benton, Evonne McArthur…·Douglas M. Ruderfer

The paper develops a method to identify deleterious noncoding variants by analyzing changes in CTCF binding activity across genomic loci and finds that loss of CTCF binding is associated with rare variants.

1 citation

humanwhole-genome sequencing

𝕏 PostBluesky

GeneticsFEBS Open BioPeer-reviewedMar 5, 2021

CRISPR-based knockin mutagenesis of the pioneer transcription factor FOXA1; optimization of strategies for multi-allelic proteins in cancer cells

Li Shen, Joseph P. Garay, Colby A. Tubbs, Hector L. Franco

The paper optimizes CRISPR-based knockin strategies for editing multi-allelic proteins in cancer cells, demonstrating successful mutation of FOXA1 in MCF-7 cells.

6 citations

humanCRISPR screen

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