Mary Lauren Benton

The paper uses nanopore sequencing and DNAscent to measure replication fork progression and origin/termination sites in Drosophila, revealing non-uniform fork speeds and variable origin positions.

This study shows that ophiobolin A induces PANoptosis in breast cancer cells through RIPK1-dependent mechanisms, leading to lytic and pro-inflammatory cell death.

The paper develops a method to identify deleterious noncoding variants by analyzing changes in CTCF binding activity across genomic loci and finds that loss of CTCF binding is associated with rare variants.

This study shows BRWD3 promotes KDM5 degradation, which maintains H3K4 methylation levels by balancing H3K4me1 and H3K4me3.

The paper maps de novo telomere addition hotspots in yeast using a high-throughput method and computational analysis, showing enrichment in subtelomeres and Cdc13 binding.

The paper shows that nucleoporins, specifically Elys, are required for ORC2 loading onto chromatin and proper replication initiation in Drosophila.

The paper maps and characterizes R-loops during Drosophila embryogenesis, showing developmental plasticity in their abundance and localization without changes in transcriptional program.

The paper introduces an explainable t-SNE method for scRNA-seq data that improves clustering performance and interpretability while addressing limitations of traditional t-SNE.

The paper functionally annotates rare structural variants in the human brain by integrating SV calling with RNA-seq data to assess their regulatory effects and prioritize pathogenic deletions.

The paper evaluates enhancer identification methods across four contexts, finding significant overlap but also substantial differences in genomic distribution, evolution, and function, and develops a database to address these challenges.