Author

Melissa Joy Call

The University of MelbourneORCID 0000-0001-7684-5841Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein design· 2 Assay:proteomics· 2 Approach:diffusion model· 1 Approach:experimental assay· 1 Assay:protein sequence· 1

Frequent Co-Authors

Julie V. NguyeniD· 3 shared Matthew Edwin CalliD· 3 shared Ashleigh S DaveyiD· 1 shared Assaf ElazariD· 1 shared Bernadine G. C. LuiD· 1 shared Dale J. CallejaiD· 1 shared Damien ThéveniniD· 1 shared David KomanderiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiophysics

Julie V. NguyenORCID

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3 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 15, 2025

Deep learning-based joint sequence-structure de novo membrane protein design

Lucas S. P. Rudden, Remo Bättig, Vinnie Andrews…·Patrick Barth

This paper introduces TMDiffusion, a deep learning model for designing membrane proteins, achieving high experimental success and accurate structural predictions.

3 citations

protein structureprotein sequence

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedJul 23, 2024

Mutational Profiling of SARS-CoV-2 PLpro in human cells reveals requirements for function, structure, and drug escape

Xinyu Wu, Margareta Go, Julie V. Nguyen…·Melissa Joy Call

The paper uses Deep Mutational Scanning to analyze SARS-CoV-2 PLpro mutations, identifying functional residues and drug-escape variants.

24 citationstop 2%

humanproteomics

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Synthetic BiologyeLifePeer-reviewedApr 19, 2022

De novo designed transmembrane domains tune engineered receptor functions

Assaf Elazar, Nicholas J. Chandler, Ashleigh S Davey…·Sarel Jacob Fleishman

The paper designs transmembrane domains to control receptor function, showing that oligomeric state affects CAR T cell activity and cytokine release.

58 citationstop 3%

humanproteomics

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