Author

Lucas S. P. Rudden

École Polytechnique Fédérale de LausanneORCID 0000-0002-4753-8890Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Research Focus:protein design· 2 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:diffusion model· 1 Approach:experimental assay· 1

Frequent Co-Authors

Patrick BarthiD· 2 shared Aisima Chatzi Souleiman· 1 shared Andreas FüglistaleriD· 1 shared Caroline ArberiD· 1 shared Christine Von Gunten· 1 shared Cynthia PéreziD· 1 shared Damien ThéveniniD· 1 shared Flora BirchiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiophysics

Patrick BarthORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiophysicsbioRxivPreprintAug 15, 2025

Deep learning-based joint sequence-structure de novo membrane protein design

Lucas S. P. Rudden, Remo Bättig, Vinnie Andrews…·Patrick Barth

This paper introduces TMDiffusion, a deep learning model for designing membrane proteins, achieving high experimental success and accurate structural predictions.

3 citations

protein structureprotein sequence

𝕏 PostBluesky

BioengineeringbioRxivPreprintMar 14, 2025

Designed allosteric biosensors for engineered T cell therapy of cancer

Jan A. Rath, Lucas S. P. Rudden, Nazila Nouraee…·Caroline Arber

This paper develops T-SenSER, a synthetic biosensor for T cells that enhances anti-tumor responses by sensing TME factors like VEGF and CSF1, showing improved efficacy in lung cancer and multiple myeloma models.

2 citations

humanproteomics

𝕏 PostBluesky