Gregory Howard Borschel

The paper shows that denervation shifts NGF receptor signaling in corneal epithelial stem cells from TrkA-AKT to p75NTR-JNK, explaining limited rhNGF efficacy in neurotrophic keratopathy and suggesting receptor-selective modulation as a therapy.

This paper applies optical tissue clearing to study nerve regeneration in rats, enabling 3D morphological analysis of nerves and their targets with high precision and speed.

This paper develops a biodegradable nerve wrap that locally delivers tacrolimus to promote axonal regeneration and functional recovery with reduced systemic drug exposure.