Jennifer Zhang

Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decreases ISR activation in DRG neurons

This paper shows that diroximel fumarate (DRF) reduces MGO-induced pain hypersensitivity in mice by activating Nrf2 and decreasing ISR activation in DRG neurons.

Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress response

This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.

Optical Tissue Clearing Enables Rapid, Precise and Comprehensive Assessment of Three-Dimensional Morphology in Experimental Nerve Regeneration Research

This paper applies optical tissue clearing to study nerve regeneration in rats, enabling 3D morphological analysis of nerves and their targets with high precision and speed.

A Biodegradable, Tacrolimus-releasing Nerve Wrap Promotes Peripheral Nerve Regeneration

This paper develops a biodegradable nerve wrap that locally delivers tacrolimus to promote axonal regeneration and functional recovery with reduced systemic drug exposure.