Bruce J. Gluckman

This study investigates the relationship between seizures and spreading depolarization (SD) in rats, finding that extracellular space (ECS) shrinkage, not oxygenation breakdown, precedes SD during seizure transitions.

This paper introduces a low-cost, high-fidelity epilepsy monitoring unit for long-term continuous recording of seizures and spreading depolarization in freely moving rats.

The paper optimizes an unscented Kalman filter for embedded platforms, achieving 27x faster computation with maintained accuracy in a rat sleep-wake model.

The paper develops a mechanistic neural mass model based on Hodgkin-Huxley principles to simulate brain rhythms and pathophysiological dynamics.

The paper examines sleep-wake regulatory nuclei in rats using long-term single- and multi-unit recordings, finding differences in activity profiles compared to previous studies when correlated with cortical and behavioral data.

This study shows that functional hyperemia drives fluid exchange in the paravascular space by interacting with brain tissue deformability.

The paper investigates the relationship between spreading depression and spontaneous seizures in two animal models of chronic epilepsy, finding that SD is associated with a third of seizures and contributes to seizure clustering.

This study shows that applied electric fields can modulate and prevent spreading depression in brain slices by altering its propagation path and speed.