Author

Muhan Wang

Purdue University West LafayetteORCID 0000-0001-7786-4825Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Assay:electronic health records· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Chongli YuaniD· 3 shared Jingliang ZhangiD· 3 shared Kyle W. WettschurackiD· 3 shared Manasi Suchit HalurkariD· 3 shared Maria I. Olivero-AcostaiD· 3 shared Morgan J. RobinsoniD· 3 shared William C. SkarnesiD· 3 shared Yang YangiD· 3 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Chongli YuanORCID

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3 papers

Recent·Most cited

NeuroscienceNeuronPeer-reviewedSep 1, 2026

Autism-associated SCN2A deficiency disrupts cortico-striatal circuitry in human brain assembloids

Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu…·Yang Yang

This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.

4 citationstop 2%

humanspatial transcriptomics

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NeuroscienceEpilepsiaPeer-reviewedJul 30, 2026

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

Maria I. Olivero-Acosta, Morgan J. Robinson, Zhefu Que…·Yang Yang

This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.

DOI 10.1002/epi.70392

humanscRNA-seq

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NeuroscienceJournal of NeurosciencePeer-reviewedNov 18, 2024

Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation

Zhefu Que, Maria I. Olivero-Acosta, Morgan J. Robinson…·Yang Yang

This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.

20 citationstop 3%

humanelectronic health records

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