Author
Purdue University West LafayetteORCID 0000-0002-7268-8188Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu…·Yang Yang
This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.
Maria I. Olivero-Acosta, Morgan J. Robinson, Zhefu Que…·Yang Yang
This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.
Jiaxiang Wu, Xiaoling Chen, Jingliang Zhang…·Yang Yang
This study uses brain organoids and assembloids with microglia to show region-specific microglial diversity and their response to SCN2A mutation-induced neuronal hyperactivity.
Jingliang Zhang, Muriel Eaton, Xiaoling Chen…·Yang Yang
This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.
Kyle W. Wettschurack, William C. Skarnes, Enrica Pellegrino…·Yang Yang
The paper develops an all-RNA prime editing system achieving over 95% editing efficiency in human iPSCs with minimal off-target effects.
Zhefu Que, Maria I. Olivero-Acosta, Morgan J. Robinson…·Yang Yang
This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.