Yang Yang

This study shows that Scn2a-deficient mice have altered serotonergic function and different behavioral responses to psilocybin compared to wild-type mice.

This study shows that inducing Kv1.1 expression in Scn2a-deficient mice reduces neuronal hyperexcitability and improves sociability without affecting wild-type mice.

This paper develops an acoustofluidic patch for transdermal biosensing and drug delivery, demonstrating its ability to detect and reverse acute allergic reactions in mice.

This paper introduces Brainobot, a biohybrid robotic system using brain organoid reservoir computing to enable real-world decision-making tasks like object grasping and laser chasing with high efficiency and low energy consumption.

This study quantifies information-processing-like properties of human cortical organoids using a functional phenotyping framework, linking network function to disease-related mutations and pharmacological perturbations.

This study shows that SCN2A deficiency in human brain assembloids disrupts cortico-striatal circuitry by impairing axonal projections and synaptic transmission, leading to hyperexcitability.

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.

This study shows that inhibiting the cortical amygdala reduces alcohol intake in dependent mice and restores thalamic connectivity during withdrawal.

This study investigates the molecular effects of SCN2A loss-of-function in patient-derived neurons, revealing NMD activation, isoform-specific dysregulation, and lncRNA network perturbations.

The paper identifies three subtypes of NS-LUAD using RNA-seq data and develops a 60-gene signature that predicts survival across subgroups.

This study uses brain organoids and assembloids with microglia to show region-specific microglial diversity and their response to SCN2A mutation-induced neuronal hyperactivity.

This paper shows that gene therapies can reduce absence seizures in DBA/2J mice with Scn2a deficiency by restoring NaV1.2 or introducing human KV1.1.

This study uses vascularized neuroimmune organoids to model sporadic Alzheimer's disease and test drug efficacy.

This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.

The paper develops an all-RNA prime editing system achieving over 95% editing efficiency in human iPSCs with minimal off-target effects.

This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.

The paper identifies a functional coupling between Slack and NaV1.6 that enhances quinidine blockade of Slack, suggesting a new approach for treating KCNT1-related epilepsy.

OpenPBTA provides a collaborative platform to genomically characterize 1,074 pediatric brain tumors and 22 cell lines, offering analysis modules and somatic datasets for research and clinical applications.

This study shows that severe NaV1.2 deficiency increases neuronal excitability in adult mice, challenging the current understanding of its role in autism and epilepsy.

The paper identifies six mutational signatures of complex genomic rearrangements in cancer, revealing new mechanisms and a prostate cancer-specific signature.

This study investigates the effects of the SCN2A L1342P variant in human iPSC-derived neurons, showing increased excitability and resistance to phenytoin, but responsiveness to PTx3.

This paper uses bifurcation theory to analyze how paclitaxel induces hyperexcitability in DRG neurons, identifying Nav1.8 and delayed rectifier potassium channels as critical factors.

This paper characterizes a Scn2a gene trap knockout mouse model with reduced Nav1.2 expression, showing behavioral and physiological abnormalities associated with Scn2a deficiency.

This study shows that inhibiting Lipocalin-2 and Early Growth Response Protein 1 promotes oligodendrocyte differentiation and remyelination after white matter injury.

This study shows that methylglyoxal (MGO) enhances resilience to chronic stress and alleviates depression-like symptoms by promoting synaptic plasticity through TrkB activation and BDNF expression.