Author

Yutaka Itokazu

Augusta UniversityORCID 0000-0001-7800-8262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Takahiro FuchigamiiD· 2 shared Alvin V. TerryiD· 1 shared Dongpei LiiD· 1 shared Robert K. YuiD· 1 shared Toshio Ariga· 1 shared Wayne D. Beck· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 5 mutual co-author links

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2 shared papersNeuroscience

Takahiro FuchigamiORCID

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3 papers

Recent·Most cited

NeuroscienceMethods in molecular biologyPeer-reviewedJan 1, 2026

Gangliosides in neural stem cell fate determination and nerve cell specification--preparation and administration

Yutaka Itokazu, Toshio Ariga, Takahiro Fuchigami, Dongpei Li

This paper investigates the role of gangliosides GD3 and GM1 in neural stem cell fate and neuronal differentiation, showing their ability to restore NSC pools and promote neuronal functions through epigenetic and mitochondrial mechanisms.

5 citationstop 1%

mouseexperimental assay

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Pharmacology & ToxicologybioRxivPreprintMar 31, 2025

GM1 and GD3 Gangliosides Attenuate NGF-TrkA and BDNF-TrkB Signaling Dysfunction Associated with Acute Diisopropylfluorophosphate Exposure in Mouse Brain

Yutaka Itokazu, Wayne D. Beck, Alvin V. Terry

This paper shows that intranasal gangliosides GM1 and GD3 prevent organophosphate-induced neurotrophin signaling dysfunction in mice, protecting against cognitive and depressive symptoms.

DOI 10.1101/2025.03.31.646417

mouseproteomics

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NeuroscienceGliaPeer-reviewedSep 5, 2023

Ganglioside GD3 regulates neural stem cell quiescence and controls postnatal neurogenesis

Takahiro Fuchigami, Yutaka Itokazu, Robert K. Yu

This study shows that GD3 deletion in postnatal radial glia-like NSCs promotes NSC activation, reduces adult NSC pools, and impairs neurogenesis and cognitive functions.

20 citations

mouseexperimental assay

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