Casey Ryan Hanson

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

The paper uses ultra high-throughput methylation sequencing to study DNA methylation changes during colorectal cancer progression from normal tissue to adenocarcinoma.

The paper develops a method to identify transcription factors regulating drug response by integrating genotype-phenotype data with TF binding predictions.

This study introduces pGENMi, a probabilistic model that integrates multi-omics data to identify transcription factors regulating cell line response to cytotoxic treatment, finding 41% validation rate for predicted associations.