Author

Gat Krieger

Weizmann Institute of Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ariel Jaimovich· 3 shared Doron LipsoniD· 3 shared Aaron M. HorningiD· 2 shared Annika K K WeimeriD· 2 shared Edward D. EspliniD· 2 shared Eti Meiri· 2 shared Hayan LeeiD· 2 shared James M. FordiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Ariel Jaimovich

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Author profile →

5 papers

Recent·Most cited

Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules

Alexandre Pellan Cheng, Itai Rusinek, Aaron Sossin, Adam J. Widman, Eti Meiri, Gat Krieger, Ori Hirschberg, Doron Shem Tov, Shlomit Gilad, Ariel Jaimovich, Omer Barad, Sammantha Avaylon, Srinivas Rajagopalan, Abigail G. Thress, Catherine J. Potenski, , Dan Avi Landau

This paper introduces ppmSeq, a sequencing technology that improves accuracy and efficiency in detecting SNVs by sequencing both DNA strands, showing superior performance in clinical applications like ctDNA detection.

bioRxiv · Aug 11, 2025 · PreprintGenomics

Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair

Jennifer McDaniel, Vaidehi Patel, Nathan D. Olson, Hua‐Jun He, Zhiyong He, Kenneth D. Cole, Alexander A Gooden, Anthony D. Schmitt, Kristin L Sikkink, Fritz Joachim Sedlazeck, HarshaVardhan Doddapaneni, Shalini N. Jhangiani, Donna Marie Muzny, Marie‐Claude Gingras, Heer Hemant Mehta, , Justin M. Zook

The paper describes a comprehensive genomic dataset from a tumor-normal pair with broad consent, generated using multiple sequencing technologies for benchmarking somatic variant detection.

Scientific Data · Jul 16, 2025Peer-reviewedGenomics

Global loss of promoter-enhancer connectivity and rebalancing of gene expression during early colorectal cancer carcinogenesis

Yizhou Zhu, Hayan Lee, Shannon M. White, Annika K K Weimer, Emma Monte, Aaron M. Horning, Stephanie A. Nevins, Edward D. Esplin, Kristina Paul, Gat Krieger, Zohar Shipony, Roxanne Chiu, Rozelle Laquindanum, Thomas V. Karathanos, Melissa W. Y. Chua, , Michael P. Snyder

This study shows that early colorectal cancer loses promoter-enhancer connectivity, leading to gene expression changes and a two-phase model of transcriptional regulation.

Nature Cancer · Oct 30, 2024Peer-reviewedGenomics

Ultra high-throughput whole-genome methylation sequencing reveals trajectories in precancerous polyps to early colorectal adenocarcinoma

Hayan Lee, Gat Krieger, Tyson A. Clark, Aziz Khan, Casey Ryan Hanson, Yizhou Zhu, Nasim Bararpour, Aaron M. Horning, Edward D. Esplin, Stephanie A. Nevins, Annika K K Weimer, Eti Meiri, Shlomit Gilad, Sima Benjamin, Danit Lebanony, , Michael P. Snyder

The paper uses ultra high-throughput methylation sequencing to study DNA methylation changes during colorectal cancer progression from normal tissue to adenocarcinoma.

bioRxiv · May 30, 2022 · PreprintGenomics

Independent evolution of transcript abundance and gene regulatory dynamics

Gat Krieger, Offir Lupo, Avraham A. Levy, Naama Barkai

The paper profiles gene expression in related yeast species across hundreds of conditions to distinguish transcriptional regulation from expression level variation, finding that promoter strength changes drive divergence without altering network positioning.

Genome Research · Jul 1, 2020Peer-reviewedSystems Biology