Joshua C. Saldivar

The paper investigates how anoxia-tolerant killifish embryos maintain genomic stability by relying on ATR kinase for DNA replication during oxygen starvation.

This study shows that the ATR-enforced S/G2 checkpoint ensures DNA replication completion and genome stability by preventing premature mitotic entry.

The paper identifies the p53-p21-RB1 axis as a determinant of breast cancer sensitivity to ATR inhibition, showing it drives G2-to-G0 cell cycle exit and is modulated by MDM2.

This study identifies a phosphorylation code in MED1 that coordinates transcription condensate dynamics with DNA replication, showing its importance for histone biosynthesis and DNA damage prevention.