Author

Laurenz Holcik

University of ViennaORCID 0000-0001-7855-3770Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metagenomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Arndt von HaeseleriD· 2 shared Christoph BockiD· 1 shared Christopher EskiD· 1 shared Florian PflugiD· 1 shared Juergen A. KnoblichiD· 1 shared Julia NaasiD· 1 shared Lina DobnikariD· 1 shared Maria NovatchkovaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBioinformatics

Arndt von HaeselerORCID

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2 papers

Recent·Most cited

BioinformaticsNature CommunicationsPeer-reviewedNov 26, 2025

Genomic GC bias correction improves species abundance estimation from metagenomic data

Laurenz Holcik, Arndt von Haeseler, Florian Pflug

This paper introduces GuaCAMOLE, a method to correct GC bias in metagenomic data, improving species abundance estimation across 3435 colorectal cancer gut microbiomes.

2 citations

metagenomicsstatistical model

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Developmental BiologybioRxivPreprintNov 15, 2024

Reconstitution of Human Brain Cell Diversity in Organoids via Four Protocols

Julia Naas, Meritxell Balmaña, Laurenz Holcik…·Juergen A. Knoblich

The paper evaluates four organoid protocols to recreate human brain cell diversity, identifies factors affecting variability, and introduces a scoring system to assess differentiation propensities.

2 citations

humanscRNA-seq

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