Maria Novatchkova

The paper develops COSCO to map neuronal connectivity in cerebral organoids and shows self-organizing network motifs and disease-related topological changes.

This study shows that long-term human cerebral organoids replicate postnatal interneuron migration, revealing chain migration and genetic factors linked to neurodevelopmental disorders.

The paper identifies a noncanonical retrotransposon transmission mechanism in Drosophila that bypasses the need for viral envelope proteins.

The paper identifies three urinary biomarkers for clear cell renal cell carcinoma using multi-omics analysis and develops a diagnostic score with 96% accuracy.

This study uses a human cardioid injury platform to investigate immune-ECM-cardiomyocyte interactions in fetal cardiac repair, identifying key signaling pathways and cellular behaviors involved in regeneration.

This study identifies SPARK as a conserved multi-protein complex essential for vertebrate fertilization, linking gamete recognition to membrane fusion.

The paper identifies molecular differences between regenerating blastema and non-regenerating CSD in axolotl limbs and uses Wnt3a expression to induce cartilage bridging in CSD.

The paper shows that the Drosophila Piwi-piRNA pathway silences transposons by degrading their RNA via the nuclear exosome, with TEsup proteins facilitating this process.

This study identifies CLEC18A as a regulator of clear cell renal cell carcinoma progression by interacting with sulfated GAGs and shows its expression is linked to improved patient survival.

This study shows connective-tissue cells are essential for axolotl limb regeneration, making up 75% of blastema cells and requiring specific signaling for regeneration.

The paper evaluates four organoid protocols to recreate human brain cell diversity, identifies factors affecting variability, and introduces a scoring system to assess differentiation propensities.

The paper identifies a dual ribosomal system in zebrafish, showing maternal and somatic ribosomes are both active and can form hybrid ribosomes in the embryo.

The paper profiles mitochondrial activity, morphology, and associated molecular changes during zebrafish embryogenesis, identifying increased ER-mitochondria contacts and mitochondrial fusion as key contributors to mitochondrial activation.

This paper develops a multi-chamber cardioid platform to study human heart development and defects by generating compartment-specific gene expression, morphology, and function.

This study identifies ARID1B's role in axon projection of callosal projection neurons, showing its haploinsufficiency leads to structural underconnectivity and agenesis of the corpus callosum.

The paper integrates transcriptome and proteome data from human brain organoids to uncover posttranscriptional regulation of ribosomal genes during corticogenesis.

This study compares the effects of exogenous and endogenous ECM on neuroepithelial development in human telencephalic organoids, showing rapid polarization with exogenous ECM and gradual acquisition with endogenous ECM.

This study identifies the HUSH complex as an epigenetic regulator of protocadherin expression in neurons, affecting brain development and neuronal diversity in mice and humans.

The paper identifies a stress signature in brain organoid scRNA-seq data and introduces Gruffi to remove stressed cells, improving developmental accuracy.

This study identifies PCYT2 as critical for muscle health and aging, showing its deficiency causes muscle weakness and aging, and demonstrates therapeutic potential through AAV-based delivery.

This study uses cerebral organoids to show that TSC2 mutations cause over-proliferation of caudal late interneuron progenitors, leading to Tuberous Sclerosis Complex.

This study uses reciprocal zebrafish-medaka hybrids to show that maternal factors primarily control the timing of zygotic genome activation.

This study identifies SPACA4 as an essential sperm protein required for zona pellucida penetration during mammalian fertilization in mice.

The paper identifies two lectins, Clec4g and CD209c, that bind to conserved glycosylation sites on SARS-CoV-2 Spike and reduce viral infections.

The paper reveals how the piRNA pathway connects to the heterochromatin machinery in Drosophila through SUMOylation of Panoramix and its interaction with Sov.

This study identifies ZFP462's role in restricting endodermal gene expression by targeting transposon-derived enhancers and modulating histone methylation in mouse embryonic stem cells.

This paper establishes self-organizing cardioids from human pluripotent stem cells that form chamber-like structures and identifies signaling pathways governing their development.

This study identifies the role of the SFiNX complex dimerization in enabling co-transcriptional silencing via molecular condensate formation in Drosophila.

This study identifies SFiNX, a complex required for Piwi-mediated co-transcriptional silencing in Drosophila, revealing its role in piRNA-guided heterochromatin formation.