Juergen A. Knoblich

The paper develops COSCO to map neuronal connectivity in cerebral organoids and shows self-organizing network motifs and disease-related topological changes.

This study shows that long-term human cerebral organoids replicate postnatal interneuron migration, revealing chain migration and genetic factors linked to neurodevelopmental disorders.

This study shows that adult mice can reorganize brain circuits remotely after visual cortex injury, with adult neurogenesis contributing to functional recovery in olfactory processing.

The paper introduces a tissue-clearing framework and mesoSPIM-ultra system for large-scale single-neuron tracing in cleared mouse tissue.

This paper uses cerebral organoids to model Tuberous Sclerosis Complex and identifies mechanisms of neural activity changes in epileptogenesis, showing potential for drug testing.

GTestimate improves scRNA-seq normalization by using the Good-Turing estimator to better estimate relative gene expression and cell-cell distances.

The paper evaluates four organoid protocols to recreate human brain cell diversity, identifies factors affecting variability, and introduces a scoring system to assess differentiation propensities.

The paper explains the clonal composition of neural organoids using a neutral competition model that accounts for observed lineage size variability.

The paper uses CRISPR and single-cell transcriptomics to screen ASD risk genes in brain organoids, identifying developmental defects and regulatory modules linked to autism.

This study identifies ARID1B's role in axon projection of callosal projection neurons, showing its haploinsufficiency leads to structural underconnectivity and agenesis of the corpus callosum.

The paper integrates transcriptome and proteome data from human brain organoids to uncover posttranscriptional regulation of ribosomal genes during corticogenesis.

This study compares the effects of exogenous and endogenous ECM on neuroepithelial development in human telencephalic organoids, showing rapid polarization with exogenous ECM and gradual acquisition with endogenous ECM.

This study identifies the HUSH complex as an epigenetic regulator of protocadherin expression in neurons, affecting brain development and neuronal diversity in mice and humans.

The paper identifies a stress signature in brain organoid scRNA-seq data and introduces Gruffi to remove stressed cells, improving developmental accuracy.

This study uses cerebral organoids to show that TSC2 mutations cause over-proliferation of caudal late interneuron progenitors, leading to Tuberous Sclerosis Complex.

This study shows that expanded CAG repeats in HTT disrupt neural progenitor expansion and differentiation in human cerebral organoids, suggesting abnormal neurodevelopment in Huntington disease.

The paper analyzes histone modifications in Drosophila neural stem cells and their progeny to understand lineage decisions and epigenetic regulation during CNS development.

The paper identifies a human accelerated region in Chromosome 14q12 that enhances forebrain expansion through increased enhancer activity in transgenic mice and organoids.

The paper identifies odd-paired (opa) as a key regulator of temporal patterning in neural progenitors through an incoherent feedforward loop involving Osa and D.

The paper introduces a non-toxic, simplified tissue clearing method called 2Eci that enables broad applicability across multiple species and tissues.

This paper describes a method to model human cortical interneuron migration using fused dorsal-ventral cerebral organoids and demonstrates directional migration inhibited by AMD3100.