Yu Chen

The paper investigates how HIF-1 and HIF-2 subunits exhibit distinct binding dynamics and gene regulation despite sharing the same DNA binding specificity, revealing the role of intrinsically disordered regions in chromatin binding and target selectivity.

The paper introduces TSA-seq to identify decondensed large-scale chromatin regions (DLCDs) and shows their association with chromatin domain boundaries.

The paper introduces SPIN, a method to identify genome-wide nuclear spatial localization patterns by integrating nuclear compartment mapping and chromatin interaction data.

The paper introduces TSA-Seq, a method to measure chromosomal distances to nuclear structures and reveals a spatial gradient in genome activity correlated with nuclear compartments.