Claudia Cattoglio

This study uses single-molecule tracking to show Sox9 dynamics change during intestinal organoid differentiation and fetal-like reprogramming, with overexpression causing morphological and functional shifts.

This study investigates how NuA4/TIP60 complex acetylates and loads H2A.Z onto chromatin to regulate transcription, showing that acetylation precedes chromatin incorporation at promoters.

The paper identifies HR factors that inhibit dual AAV vector transduction and shows that inhibiting these factors improves transgene reconstitution.

The paper reveals that pioneer transcription factors use mesoscale chromatin confinement to efficiently search for and bind to closed chromatin regions in live cells.

The paper investigates how HIF-1 and HIF-2 subunits exhibit distinct binding dynamics and gene regulation despite sharing the same DNA binding specificity, revealing the role of intrinsically disordered regions in chromatin binding and target selectivity.

This study identifies Klf5 as a key regulator of bi-potential cell fate in mouse preimplantation embryos by controlling both ICM and TE specification genes.

The paper investigates how enhancer-promoter interactions and transcription are affected by acute loss of CTCF, cohesin, WAPL, and YY1, finding minimal effects on E-P interactions and gene expression despite 3D genome perturbations.

The paper investigates how transcriptional regulatory elements influence the 3D organization of microTADs in mouse stem cells.

This study uses live-cell single-molecule imaging to show that TF low-complexity domains form dynamic, selective interaction hubs that stabilize DNA binding and activate transcription.