Omid Gholamalamdari

This paper develops an ex vivo EU-click labeling protocol to visualize nascent RNA in C. elegans intestines, showing EU incorporation reflects rRNA transcription and localizes to the fibrillar zone.

The paper examines genome organization in human cells relative to nuclear locales, finding that gene expression and replication timing correlate with different nuclear structures and that LADs and iLADs compete for lamina attachment.

The paper introduces TSA-seq to identify decondensed large-scale chromatin regions (DLCDs) and shows their association with chromatin domain boundaries.