Laura Sebastián Monasor

This study shows that microbiota-derived short chain fatty acids (SCFA) increase Aβ plaque deposition in Alzheimer's disease by promoting microglial activation and ApoE upregulation.

This study shows that loss of NPC1 in microglia increases phagocytic uptake and impairs lipid trafficking, leading to myelin accumulation and potential therapeutic implications.

The paper develops a method to analyze the secretome of mouse brain cells and identifies cell type-specific secreted proteins, revealing proteolytic cleavage of membrane proteins.

This study identifies proteomic changes in microglia during Alzheimer's disease progression in mouse models, showing fibrillar Aβ drives microglial dysfunction.