Cell BiologyActa Biochimica et Biophysica SinicaPeer-reviewed
Targeting USP2 induces degradation of PML-RARα with or without drug-resistant mutations in acute promyelocytic leukemia
Jie Zhang, Wenxuan Wu, Yun Wang…·Yingli Wu
This study shows that inhibiting USP2 reduces PML-RAR protein levels in APL cells, including those with drug-resistant mutations, and induces apoptosis.
2 citations