The sphingosine-1-phosphate receptor functional antagonist fingolimod exacerbates neuroinflammation and tau pathology in a mouse model of tauopathy
Michelle Diane Rudman, Alexandra Litvinchuk, Cathryn T Smith, Javier Remolina Serrano, Melissa Manis, Xin Bao, Carla M. Yuede, Jason D. Ulrich, David M. Holtzman
This study shows that fingolimod worsens T cell infiltration and tau pathology in a mouse model of tauopathy, despite reducing peripheral T cells.
bioRxiv · Sep 5, 2026 · PreprintNeuroscience