Cathryn T Smith

This study shows that fingolimod worsens T cell infiltration and tau pathology in a mouse model of tauopathy, despite reducing peripheral T cells.

This study shows that APOE4 increases lipid droplet accumulation and alters their composition in microglia, resembling a pro-inflammatory state, and overlaps with AD-associated proteomes.

This study investigates how APOE4 affects microglial immunometabolism across age, amyloid pathology, and inflammation using multi-omics approaches.

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.