Jason D. Ulrich

This study shows that reducing APOE4 in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and improves vascular function in a mouse model.

This study shows that an engineered bacterium worsens neurodegeneration in a tauopathy mouse model by altering immune responses, while the unmodified strain has no effect.

This study shows that fingolimod worsens T cell infiltration and tau pathology in a mouse model of tauopathy, despite reducing peripheral T cells.

This study shows that cDC1 cells prime CD8+ T cells, which then exacerbate tau-mediated neurodegeneration in mice.

This study shows that Ch25h/25HC promotes neuroinflammation and neurodegeneration in a tauopathy mouse model by enhancing proinflammatory signaling and impairing sterol synthesis.