Carla M. Yuede

This study shows that fingolimod worsens T cell infiltration and tau pathology in a mouse model of tauopathy, despite reducing peripheral T cells.

This paper characterizes YX84, a novel neuroactive steroid with dual GABA A receptor agonism and NMDA receptor inhibition, showing favorable behavioral tolerability.

This study shows that vestibular function remains normal in Vglut3-/- mice despite severe reduction in glutamatergic synaptic transmission, suggesting non-quantal transmission compensates for the loss.

This paper shows that lemborexant reduces infarct volume and improves motor recovery in a mouse model of ischemic stroke by stabilizing sleep.

The paper shows that activating specific neurons induces hypothermia and metabolic changes that reduce brain injury after stroke, with benefits lost when temperature is normal.

This study shows that aging reduces motivation in mice by decreasing Bdnf expression in the ventral tegmental area, and that this effect can be replicated by Bdnf knockdown in young mice.

The paper investigates the role of δ subunit-containing GABA-A receptors on parvalbumin positive neurons in shaping electrocortical activity during sleep states, finding altered EEG patterns in their absence.

This study shows that USP7 deletion in mice causes neurological phenotypes, including synaptic proteome changes and dendritic spine defects, independent of p53.

This study identifies heterozygous lysosomal enzyme gene mutations as risk factors for Alzheimer's disease and validates their impact on amyloid-beta processing using mouse models.

This study shows that Kir6.2-KATP channels regulate glycolytic flux, neuronal activity, and sleep-wake transitions by modulating lactate dynamics and metabolic stability.

This paper develops microimmunoelectrodes for electrochemical detection of dynorphin, showing sensitivity in the attomolar range and selectivity over other opioids.