Author

Lesia O. Kurlak

University of NottinghamORCID 0000-0001-7938-6994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Carlos EscuderoiD· 2 shared Estefanny Escudero-GuevaraiD· 2 shared Felipe TroncosoiD· 2 shared Hermes SandovaliD· 2 shared Hiten D. MistryiD· 2 shared Jesenia Acurio· 2 shared Belén IbáñeziD· 1 shared Cristian VargasiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPhysiology

Carlos EscuderoORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintMar 23, 2026

Umbilical-brain endothelial communication via TSP-1 is linked with reduced brain angiogenesis in offspring of preeclampsia

Estefanny Escudero-Guevara, Felipe Troncoso, Hermes Sandoval…·Carlos Escudero

This study shows that TSP-1 from preeclampsia affects brain endothelial function by reducing angiogenesis and altering signaling pathways.

DOI 10.64898/2026.03.19.713060

humanproteomics

𝕏 PostBluesky

PhysiologyArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewedDec 12, 2024

Extracellular vesicles from preeclampsia disrupt the blood-brain barrier via reduced claudin-5: potential role of vascular endothelial growth factor

Hermes Sandoval, Belén Ibáñez, Moisés Contreras…·Carlos Escudero

This study shows that extracellular vesicles from preeclampsia and hypoxic placentae reduce claudin-5 in the blood-brain barrier, potentially via VEGF, leading to BBB disruption and neurological deficits.

22 citationstop 1%

𝕏 PostBluesky