Extracellular vesicles from preeclampsia disrupt the blood-brain barrier via reduced claudin-5: potential role of vascular endothelial growth factor
Hermes Sandoval, Belén Ibáñez, Moisés Contreras, Felipe Troncoso, Fidel Ovídio Castro, Diego Caamaño, Lidice Mendez, Estefanny Escudero-Guevara, Francisco Nualart, Hiten D. Mistry, Lesia O. Kurlak, Manu Vatish, Jesenia Acurio, Carlos Escudero
This study shows that extracellular vesicles from preeclampsia and hypoxic placentae reduce claudin-5 in the blood-brain barrier, potentially via VEGF, leading to BBB disruption and neurological deficits.
Arteriosclerosis Thrombosis and Vascular Biology · Dec 12, 2024Peer-reviewedPhysiology