Rekha Mudappathi

This study links germline variation to tumor evolutionary dynamics in multiple myeloma, identifying TBKBP1 as a mediator of subclonal expansion and clinical outcomes.

TEATIME estimates evolutionary parameters and fitness diversity from bulk sequencing data, revealing patterns of intratumor heterogeneity across 33 cancer types.

INCLOSE identifies condition-specific cell populations by integrating single-cell omics data and metadata, revealing immune suppression in acute myeloid leukemia.

This study introduces MPET, a computational framework to analyze how intracellular transport affects surface protein expression using CITE-seq data from COVID-19 patients.