Lawrence Boise

The paper integrates coding and noncoding genome annotations to improve transcriptomic analysis, identifying clinically relevant noncoding RNAs in multiple myeloma.

Structure-optimized CD27-based CAR-T cells targeting CD70 show >80-fold improved expansion in vivo and offer a potential therapy for high-risk multiple myeloma patients.

This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.

The paper characterizes a missense mutation in EXOSC2 that affects the RNA exosome-Mtr4 interaction in yeast, showing functional consequences in RNA processing and drug sensitivity.

The paper identifies IgL translocations in multiple myeloma as a marker of poor prognosis, often misclassified as standard risk due to co-occurrence with hyperdiploidy.