Wynn K. Meyer

The paper updates the RERconverge package with faster algorithms and new analysis features for studying convergent evolution at the genomic level.

The paper compares molecular evolution differences between vertivores, invertivores, and combined carnivores, finding greater conservation in lipid and amino acid metabolism in predatory diets compared to herbivores.

The paper identifies genetic regulators of eye degeneration in cavefish using CRISPR screening and functional assays.

The paper expands RERconverge to analyze multi-categorical traits by introducing methods for ancestral state reconstruction, statistical tests, and phylogenetic permutations, showing improved performance in identifying diet-related genes and pathways.

The paper identifies proteins and regulatory elements associated with vocal learning by analyzing bat neural activity and epigenomic data.

The paper identifies six genes with relaxed evolutionary constraint in herbivorous mammals, linking dietary changes to reduced purifying selection in liver and kidney-related pathways.

TOGA integrates gene annotation and orthology inference across hundreds of genomes, improving ortholog detection and creating large comparative gene resources.

A machine learning approach identifies enhancer-phenotype associations across mammals, revealing links to brain size and behavior evolution.

The paper curates TE content in 248 mammalian genomes, finding trends in recent TE accumulation and associations with dietary habits.

A 240-species placental mammal alignment resolves constraint to single bases, estimating at least 10.7% of the human genome is constrained, with 48.5% of constrained bases unannotated.

The paper uses evolutionary constraint scores to identify functional genomic regions and finds they are enriched for variants associated with common diseases.

The paper identifies bats as a hotspot for horizontal transfer of DNA transposons, finding over 200 putative elements and shared transposons across mammals and reptiles.