Diana D. Moreno-Santillán

Elephant seal cells export iron and form lipid droplets to evade lipid peroxidation

This study identifies a unique mechanism in elephant seal cells that prevents lipid peroxidation through lipid droplet formation and iron export, rather than traditional antioxidant pathways.

Phthalate Exposure Induces Inflammatory Signaling and Suppresses Mitochondrial Function in Marine Mammal and Human Cells

This study examines how MEHP exposure affects gene expression and mitochondrial function in marine mammal and human cells, revealing species-specific responses.

Molecular signatures and cellular responses underlying hypoxic adaptation in sea turtles

The paper examines HIF gene family evolution and hypoxia transcriptional responses in hypoxia-tolerant and non-tolerant reptiles, finding distinct regulatory mechanisms in sea turtles.

Genomic comparisons shed light on the adaptive basis of brain size plasticity and chromosomal instability in the Eurasian common shrew

The paper identifies genomic and transcriptomic changes associated with chromosomal instability and seasonal brain size plasticity in the Eurasian common shrew.

Prolonged fasting and glucocorticoid exposure drive dynamic DNA methylation in elephant seals

This study investigates how prolonged fasting and glucocorticoids affect DNA methylation in elephant seals, finding transient increases in blood methylation and decreased methylation in muscle cells with glucocorticoid exposure.

Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements

The paper identifies proteins and regulatory elements associated with vocal learning by analyzing bat neural activity and epigenomic data.

Integrating gene annotation with orthology inference at scale

TOGA integrates gene annotation and orthology inference across hundreds of genomes, improving ortholog detection and creating large comparative gene resources.

Relating enhancer genetic variation across mammals to complex phenotypes using machine learning

A machine learning approach identifies enhancer-phenotype associations across mammals, revealing links to brain size and behavior evolution.

Insights into mammalian TE diversity via the curation of 248 mammalian genome assemblies

The paper curates TE content in 248 mammalian genomes, finding trends in recent TE accumulation and associations with dietary habits.

Title: Leveraging Base Pair Mammalian Constraint to Understand Genetic Variation and Human Disease

The paper uses evolutionary constraint scores to identify functional genomic regions and finds they are enriched for variants associated with common diseases.

Chiropterans are a hotspot for horizontal transfer of DNA transposons in Mammalia

The paper identifies bats as a hotspot for horizontal transfer of DNA transposons, finding over 200 putative elements and shared transposons across mammals and reptiles.