ImmunologyNature CommunicationsPeer-reviewed
Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors
Zebin Xiao, Leslie Todd, Li Huang…·Ellen Puré
This study shows that targeting FAP+CAFs in desmoplastic pancreatic tumors reduces stromal barriers, enhances T cell infiltration, and improves response to immunotherapy.
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