Author

Ariana Huebner

The Francis Crick InstituteORCID 0000-0001-8009-4999Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Charles SwantoniD· 2 shared Nicholas McGranahaniD· 2 shared Abigail BunkumiD· 1 shared Abigail R. BarberiD· 1 shared Aimee FalzoneiD· 1 shared Andrew RowaniD· 1 shared David R. PearceiD· 1 shared Eman Khalil· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

Charles SwantonORCID

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3 papers

Recent·Most cited

Cancer BiologyLecture notes in computer sciencePeer-reviewedJan 1, 2025

Characterizing the Solution Space of Migration Histories of Metastatic Cancers with MACH2

Mrinmoy Saha Roddur, Vikram Ramavarapu, Abigail Bunkum…·Mohammed El-Kebir

The paper introduces MACH2, a method to systematically enumerate all plausible migration histories of metastatic cancers, outperforming existing methods and detecting extensive uncertainty in real cancer data.

1 citationtop 4%

humanbulk RNA-seq

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Cancer BiologyNature CommunicationsPeer-reviewedDec 17, 2024

Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography

Hannah E. Greenwood, Abigail R. Barber, Richard S. Edwards…·Timothy Howard Witney

This study uses PET imaging to assess NRF2 activation in NSCLC, showing [18F]FSPG as a marker of therapeutic resistance and a potential target for treatment.

36 citationstop 4%

humanimaging

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GenomicsbioRxivPreprintJan 7, 2019

Whole Genome Doubling mitigates Muller’s Ratchet in Cancer Evolution

Saioa López, Emilia L. Lim, Ariana Huebner…·Nicholas McGranahan

The paper investigates how whole genome doubling (WGD) in cancer may mitigate Muller’s Ratchet by reducing negative selection on mutations in essential genes after duplication.

8 citations

humanwhole-genome sequencing

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