Author

David R. Pearce

University College LondonORCID 0000-0001-8443-2924Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Robert E. HyndsiD· 3 shared Jessica C. OrriD· 2 shared Sam M. JanesiD· 2 shared Yuki IshiiiD· 2 shared Abigail R. BarberiD· 1 shared Aimee FalzoneiD· 1 shared Alexandra Y. KreinsiD· 1 shared Andrew S. FarriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

Robert E. HyndsORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 15, 2025

WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells

Jessica C. Orr, Elizabeth K. Haughey, Andrew S. Farr…·Robert E. Hynds

The paper introduces WS6 to enhance ex vivo expansion and gene editing of epithelial basal stem cells, enabling disease modeling and regenerative medicine applications.

1 citation

humanscRNA-seq

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Cell BiologyJournal of Cell SciencePeer-reviewedMar 11, 2025

Compound screening in primary human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

Yuki Ishii, Jessica C. Orr, Marie-Belle El Mdawar…·Robert E. Hynds

The paper screens 1,429 compounds in primary human airway basal cells to identify Wnt pathway activators that promote proliferation and regeneration.

7 citations

humanbulk RNA-seq

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Cancer BiologyNature CommunicationsPeer-reviewedDec 17, 2024

Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography

Hannah E. Greenwood, Abigail R. Barber, Richard S. Edwards…·Timothy Howard Witney

This study uses PET imaging to assess NRF2 activation in NSCLC, showing [18F]FSPG as a marker of therapeutic resistance and a potential target for treatment.

36 citationstop 4%

humanimaging

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