John O’Sullivan

This study shows that inhibiting Runx1 protects against heart failure with preserved ejection fraction in mice by improving diastolic function and reducing hypertrophy and pulmonary edema.

This paper optimizes two murine models of heart failure with preserved ejection fraction (HFpEF) to improve reproducibility and robustness across strains and sexes.

The paper introduces hRUV, a hierarchical method to remove unwanted variation in large-scale metabolomics data, showing improved preservation of biological signals.

The paper identifies NOTCH1 variants as a major genetic contributor to non-syndromic Tetralogy of Fallot, with 6% of patients carrying deleterious variants.