Author

Leesa J. Deterding

National Institutes of HealthORCID 0000-0001-8041-389XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Fred Bjørn LihiD· 2 shared Paul A. WadeiD· 2 shared Sara A. GrimmiD· 2 shared Yang Liu· 2 shared Eric J. MillimaniD· 1 shared James M. WardiD· 1 shared Jason G Williams· 1 shared John Anthony CidlowskiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Fred Bjørn LihORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJul 6, 2026

Short-term methionine starvation induces de novo diurnal oscillations of hepatic m6A RNA methylation

Yang Liu, Kaliopi Chrysovergis, Katina L. Johnson…·Paul A. Wade

This study shows that short-term methionine starvation causes new daily rhythms in m6A RNA methylation in mouse liver, linking methionine metabolism to circadian regulation.

DOI 10.64898/2026.07.03.736420

mousebulk RNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintMay 7, 2026

Methionine Deprivation-induced Reprogramming of Hepatic Rhythms Is Mediated by Glucocorticoid Receptor

Yang Liu, Sara A. Grimm, Fred Bjørn Lih…·Paul A. Wade

This study shows that methionine deprivation in mice reprograms hepatic circadian rhythms via glucocorticoid receptor mechanisms.

DOI 10.64898/2026.05.04.722637

mousebulk RNA-seq

𝕏 PostBluesky

GenomicsiSciencePeer-reviewedAug 22, 2025

The Loss of the H1.4 Linker Histone Impacts Nascent Transcription and Chromatin Accessibility

Nolan G. Gokey, James M. Ward, Eric J. Milliman…·Trevor Archer

The paper shows that loss of H1.4 linker histone affects chromatin accessibility, histone modifications, and gene expression, particularly impacting stress response pathways and immune-related genes.

3 citations

humanChIP-seq

𝕏 PostBluesky