Paul A. Wade

This study shows that short-term methionine starvation causes new daily rhythms in m6A RNA methylation in mouse liver, linking methionine metabolism to circadian regulation.

This study shows aging restricts colorectal tumor growth by epigenetically silencing developmental gene programs, with implications for early-onset colorectal cancer.

This study shows that methionine deprivation in mice reprograms hepatic circadian rhythms via glucocorticoid receptor mechanisms.

This study shows CHD4 prevents inappropriate gene activation by editing transcription factor binding site selection through chromatin remodeling in breast cancer cells and during reprogramming.

The paper introduces CUT&Tag-BS, a method for simultaneous profiling of histone modification and DNA methylation at single-base resolution using low-input samples.

The paper develops a method for simultaneous ATAC-seq and mRNA-seq from low-input samples, showing comparable data quality and strong promoter accessibility-gene expression association.

This study identifies the RFTS domain of DNMT1 as a reader for H3K9me3/H3Ub, showing its role in DNA methylation maintenance and genomic stability.

This study characterizes the structure-function differences between DNMT3A and DNMT3B, revealing distinct mechanisms of de novo DNA methylation and their implications in epigenomic alterations.

This study investigates how a GATA3 mutation affects the transcriptional network involving ER, FOXA1, and GATA3, showing disrupted cooperation and altered chromatin localization.