Sara A. Grimm

This study shows that intermittent heat exposure during mid-to-late gestation in mice leads to reduced anogenital distance and increased hypospadias in male embryos, without affecting gene expression in the fetal testis.

This study investigates how neonatal exposure to diethylstilbestrol disrupts uterine epithelial polarity and partial EMT state in mice, leading to long-term functional impairments and cancer risk.

This study shows that short-term methionine starvation causes new daily rhythms in m6A RNA methylation in mouse liver, linking methionine metabolism to circadian regulation.

This study shows aging restricts colorectal tumor growth by epigenetically silencing developmental gene programs, with implications for early-onset colorectal cancer.

This study shows that methionine deprivation in mice reprograms hepatic circadian rhythms via glucocorticoid receptor mechanisms.

This study identifies GLIS3 as a critical regulator of astrocyte differentiation from human neural stem cells, showing its role in gene expression and potential therapeutic relevance.

This study shows that glycogen metabolism in Sertoli cells supports germ cell colonization during early testis development through lactate production, highlighting a critical metabolic dependency.

This study identifies two distinct roles of GLIS3 in β-cell development, showing its critical function in bipotent progenitor generation and preβ-to-β cell differentiation, contributing to neonatal diabetes in GLIS3-deficient mice.

This paper identifies DNA methylation biomarker panels for multi-cancer detection and tissue-of-origin classification using blood samples, achieving high sensitivity and low false positive rates.

The paper identifies Nr2f2 as a regulator of interstitial to fetal Leydig cell differentiation in mice, linking its dysfunction to disorders of sex development.

This study shows CHD4 prevents inappropriate gene activation by editing transcription factor binding site selection through chromatin remodeling in breast cancer cells and during reprogramming.

The paper shows that Wolffian duct mesenchyme persists in female embryos and contributes to female reproductive tract formation through unique transcriptomic and anatomical changes.

The paper introduces CUT&Tag-BS, a method for simultaneous profiling of histone modification and DNA methylation at single-base resolution using low-input samples.

This study shows GLIS1 regulates trabecular meshwork function and intraocular pressure, with a human variant linked to glaucoma.

The paper develops a method for simultaneous ATAC-seq and mRNA-seq from low-input samples, showing comparable data quality and strong promoter accessibility-gene expression association.

This study shows that maternal exposure to rotenone alters DNA methylation and gene expression in offspring, with long-term effects on health and disease.

This study identifies the RFTS domain of DNMT1 as a reader for H3K9me3/H3Ub, showing its role in DNA methylation maintenance and genomic stability.

This study characterizes the structure-function differences between DNMT3A and DNMT3B, revealing distinct mechanisms of de novo DNA methylation and their implications in epigenomic alterations.

The paper identifies RUNX1 as a conserved regulator of fetal ovarian supporting cell identity, showing its interaction with FOXL2 in maintaining granulosa cell fate across species.

This study investigates how a GATA3 mutation affects the transcriptional network involving ER, FOXA1, and GATA3, showing disrupted cooperation and altered chromatin localization.