James M. Ward

The Loss of the H1.4 Linker Histone Impacts Nascent Transcription and Chromatin Accessibility

The paper shows that loss of H1.4 linker histone affects chromatin accessibility, histone modifications, and gene expression, particularly impacting stress response pathways and immune-related genes.

Fate (or state) of CA2 neurons in a mineralocorticoid receptor knockout.

The paper investigates the effects of mineralocorticoid receptor knockout on CA2 neurons, finding they adopt a CA1-like molecular and morphological phenotype.

Proteasome inhibition reprograms chromatin landscape in breast cancer

This study shows proteasome inhibition changes chromatin accessibility and transcription initiation in breast cancer cells, revealing new insights into how proteasome inhibitors affect gene expression.

BRG1 establishes the neuroectodermal chromatin landscape to restrict dorsal cell fates

This study shows BRG1 is essential for establishing the chromatin landscape in neural progenitor cells, ensuring proper expression of neuroectodermal transcription factors and preventing premature differentiation.

Distinct neuronal activity patterns induce different gene expression programs

The paper shows that distinct neuronal activity patterns induce different gene expression programs through specific mechanisms.