This study examines how pulmonary tuberculosis affects the respiratory and gut microbiomes in Ugandan adults, finding site-specific taxonomic differences but mixed results on community composition.

bioRxiv · Oct 15, 2026 · PreprintGenomics

Whole-genome characterization of Plasmodium falciparum population structure and drug resistance across Uganda and neighboring countries

Shahiid Kiyaga, Monica Mbabazi, Thomas Katairo, Victor Asua, Francis D Semakuba, Bienvenu Nsengimaana, Stephen Tukwasibwe, Innocent Wiringilimaana, Jackie Nakasaanya, Jerry Mulondo, Eric Watyekele, Catherine Maiteki‐Sebuguzi, David Patrick Kateete, Joyce Nakatumba Nabende, Daudi Jjingo, , Jessica J. Briggs

The paper characterizes the population structure and drug resistance of Plasmodium falciparum in Uganda and neighboring countries using whole-genome data, identifying key resistance-associated haplotypes.

bioRxiv · Sep 30, 2026 · PreprintGenomics

Comparative analyses of Gram-negative bacteria isolated from cancer patients with bacteraemia at the Uganda Cancer Institute

Margaret Lubwama, Lesley Hoyles, Anne L. McCartney, David Patrick Kateete, Freddie Bwanga, Edgar Kigozi, Leymon Kalema, Benon Byamugisha Asiimwe, George Katende, Fahad Lwigale, Simon Sekyanzi, Nixon Niyonzima, Jackson Orem, Henry Ddungu, Joyce Kambugu, , Jody Anne Winter

This study shows that transporting bacterial DNA at ambient temperature from Uganda to the UK allows high-quality whole-genome sequencing, revealing AMR patterns and misidentification issues in Gram-negative bacteria from cancer patients.

bioRxiv · Jul 6, 2026 · PreprintMicrobiology

High KIR diversity in Uganda and Botswana children living with HIV

John Mukisa, Samuel Kyobe, Marion Amujal, Williams Jacqueline, Eric Katagirya, Thabo Diphoko, Gaseene Sebetso, Savannah Mwesigwa, Gerald Mboowa, Gaone Retshabile, Lesedi Williams, Busisiwe Mlotshwa, Mogomotsi Matshaba, Daudi Jjingo, David Patrick Kateete, , Jill A. Hollenbach

This study analyzes KIR diversity in HIV-infected children from Uganda and Botswana, finding differences in allele frequencies and associations with disease progression.

Human Immunology · Jun 19, 2026Peer-reviewedGenomics

Targeted Metagenomics Reveals Hidden Chickenpox Epidemic Amid Mpox Surveillance in Uganda

Stephen Kanyerezi, Alisen Ayitewala, Jupiter Marina Kabahita, Hellen Rosette Oundo, Julius Sseruyange, Wilson Tenywa, Godwin Tusabe, Stacy Were, Moses Murungi, Martha Nabukyu, Valeria Nakintu, Caroline Makoha, Ivan Sserwadda, Harris Onywera, Collins Kipngetich Tanui, , Isaac Ssewanyana

The paper identifies a concurrent chickenpox outbreak during an Mpox outbreak in Uganda by analyzing metagenomic data from Mpox-negative samples.

Scientific Reports · Feb 6, 2026Peer-reviewedGenetic & Genomic Medicine

Whole genome sequencing-based characterization of mobile genetic elements in Staphylococcus aureus isolated from patients in Fort Portal Regional Referral Hospital, Western Uganda

Moses Luutu Nsubuga, Eric Katagirya, Gavin Ackers Johnson, Kia Praiscillia, Kaddu Arafat, Bwambale Wilberforce, Muwambi William Jonathan, Fahim Yiga, Leymon Kalema, Henry Ssenfuka, Richard Mulondo, Edgar Kigozi, Fred Ashaba Katabazi, Henry Kajumbula, Chloë E. James, David P. Katete

The paper characterizes mobile genetic elements in S. aureus isolates from Uganda, identifying diverse MGEs associated with virulence and antibiotic resistance.

bioRxiv · Jan 14, 2026 · PreprintGenomics

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda

David Patrick Kateete, Shakira Namakula, Edgar Kigozi, Fred Ashaba Katabazi, George William Kasule, Kenneth Musisi, Edward Wampande, Deus Lukoye, Moses Lutaakome Joloba

This study identifies compensatory mutations in rpoA/B/C genes of rifampicin-resistant M. tuberculosis isolates in Uganda, finding rpoC/Gly594Glu and rpoC/Val483Ala as the most frequent.

PLoS ONE · Dec 4, 2025Peer-reviewedMicrobiology

Gut microbial profiling of COVID-19 patients in Uganda

David Patrick Kateete, Christopher Lubega, Ronald M. Galiwango, Emmanuel Nasinghe, Monica Mbabazi, Daudi Jjingo, Alison M. Elliott

This study profiles the gut microbiome of Ugandan COVID-19 patients and identifies microbial associations with disease severity using machine learning.

bioRxiv · Jun 28, 2024 · PreprintBioinformatics